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SAM-e (s-adenosyl methionine): SAM-e naturally occurs in every cell of the body and brain and fuels over 100 metabolic reactions. In Europe, SAM-e is used as a prescription medication for depression, liver disease, and osteoarthritis (11).SAM-e supplements are synthetically derived and sold in the U. Several studies show that SAM-e works as well for depression as some anti-depression medications by increasing serotonin, dopamine, and other “feel good” brain chemicals (12, 13).If this is your situation, here are some serotonin supplements proven to help increase serotonin levels naturally.
Unfortunately, this supplement’s usefulness for depression may be more hype than substance.But SSRIs can have serious side effects and don’t work for everyone, possibly up to 40 percent of those who try them (1).Some research shows they work no better than a placebo (2).We prefer tryptophan supplements not just because studies have not conclusively found that 5-HTP helps depression, but because 5-HTP is intended for long-term use.While it’s increasing serotonin, it’s depleting other neurotransmitters like dopamine.
Tryptophan supplements fell out of favor when a contaminated batch from Japan caused thousands to fall ill in the 1980s.